A website for the analysis of protein sequence variability in terms of physicochemical descriptors of the amino acids.
For a given dataset (from alignments, deep-sequencing experiments, etc.) the main tool
will find out which property(ies) of the amino acids (volume, hydrophobicity, etc.) shape
the probability of finding each amino acid at each position of the sequence. Such kind of
analysis helps retrieve rich information about the main physicochemical constraints to
protein design, engineering and evolution, as illustrated in this application
to deep-sequencing data on a library of all mutants at all positions of an enzyme.